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Quadruplex-forming oligonucleotide targeted to the VEGF promoter inhibits growth of non-small cell lung cancer cells

BACKGROUND: Vascular endothelial growth factor (VEGF) is commonly overexpressed in a variety of tumor types including lung cancer. As a key regulator of angiogenesis, it promotes tumor survival, growth, and metastasis through the activation of the downstream protein kinase B (AKT) and extracellular...

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Detalles Bibliográficos
Autores principales:	Muench, David, Rezzoug, Francine, Thomas, Shelia D., Xiao, Jingjing, Islam, Ashraful, Miller, Donald M., Sedoris, Kara C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347295/ https://www.ncbi.nlm.nih.gov/pubmed/30682194 http://dx.doi.org/10.1371/journal.pone.0211046

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