Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes

Late endosome-resident interferon-induced transmembrane protein 3 (IFITM3) inhibits fusion of diverse viruses, including Influenza A virus (IAV), by a poorly understood mechanism. Despite the broad antiviral activity of IFITM3, viruses like Lassa virus (LASV), are fully resistant to its inhibitory e...

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Detalles Bibliográficos
Autores principales: Suddala, Krishna C., Lee, Christine C., Meraner, Paul, Marin, Mariana, Markosyan, Ruben M., Desai, Tanay M., Cohen, Fredric S., Brass, Abraham L., Melikyan, Gregory B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347298/
https://www.ncbi.nlm.nih.gov/pubmed/30640957
http://dx.doi.org/10.1371/journal.ppat.1007532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347298/
https://www.ncbi.nlm.nih.gov/pubmed/30640957
http://dx.doi.org/10.1371/journal.ppat.1007532

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