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The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex
The mitochondrial calcium uniporter is a Ca(2+) channel that regulates intracellular Ca(2+) signaling, oxidative phosphorylation, and apoptosis. It contains the pore-forming MCU protein, which possesses a DIME sequence thought to form a Ca(2+) selectivity filter, and also regulatory EMRE, MICU1, and...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347451/ https://www.ncbi.nlm.nih.gov/pubmed/30638448 http://dx.doi.org/10.7554/eLife.41112 |