Cargando…
AAV2.7m8 is a powerful viral vector for inner ear gene therapy
Adeno-associated virus (AAV) has been successfully used to deliver gene therapy to improve auditory function in mouse models of hereditary hearing loss. Many forms of hereditary hearing loss have mutations which affect the cochlear hair cells, the mechanosensory cells which allow for sound detection...
Autores principales: | Isgrig, Kevin, McDougald, Devin S., Zhu, Jianliang, Wang, Hong Jun, Bennett, Jean, Chien, Wade W. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347594/ https://www.ncbi.nlm.nih.gov/pubmed/30683875 http://dx.doi.org/10.1038/s41467-018-08243-1 |
Ejemplares similares
-
AAV8BP2 and AAV8 transduce the mammalian cochlear lateral wall and endolymphatic sac with high efficiency
por: Isgrig, Kevin, et al.
Publicado: (2022) -
Refining surgical techniques for efficient posterior semicircular canal gene delivery in the adult mammalian inner ear with minimal hearing loss
por: Zhu, Jianliang, et al.
Publicado: (2021) -
CRISPR Activation Enhances In Vitro Potency of AAV Vectors Driven by Tissue-Specific Promoters
por: McDougald, Devin S., et al.
Publicado: (2019) -
Efficient Viral Transduction in Fetal and Adult Human Inner Ear Explants with AAV9-PHP.B Vectors
por: van Beelen, Edward S. A., et al.
Publicado: (2022) -
A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear
por: Landegger, Lukas D., et al.
Publicado: (2017)