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Cereblon attenuates DNA damage-induced apoptosis by regulating the transcription-independent function of p53

Cereblon (CRBN) is the substrate receptor of the cullin 4-RING E3 ligase complex and has been employed for targeted protein degradation in the treatment of cancers. However, its normal physiological functions and molecular mechanism in the regulation of DNA damage response are largely unknown. Here...

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Detalles Bibliográficos
Autores principales: Zhou, Liang, Xu, Guoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347596/
https://www.ncbi.nlm.nih.gov/pubmed/30683842
http://dx.doi.org/10.1038/s41419-019-1317-7