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Cereblon attenuates DNA damage-induced apoptosis by regulating the transcription-independent function of p53
Cereblon (CRBN) is the substrate receptor of the cullin 4-RING E3 ligase complex and has been employed for targeted protein degradation in the treatment of cancers. However, its normal physiological functions and molecular mechanism in the regulation of DNA damage response are largely unknown. Here...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347596/ https://www.ncbi.nlm.nih.gov/pubmed/30683842 http://dx.doi.org/10.1038/s41419-019-1317-7 |