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Signatures of selection in the human antibody repertoire: Selective sweeps, competing subclones, and neutral drift
Antibodies are created and refined by somatic evolution in B cell populations, which endows the human immune system with the ability to recognize and eliminate diverse pathogens. However, the evolutionary processes that sculpt antibody repertoires remain poorly understood. Here, using an unbiased re...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347681/ https://www.ncbi.nlm.nih.gov/pubmed/30622180 http://dx.doi.org/10.1073/pnas.1814213116 |