Identifying and targeting cancer stem cells in leiomyosarcoma: prognostic impact and role to overcome secondary resistance to PI3K/mTOR inhibition

BACKGROUND: Leiomyosarcoma (LMS) is one of the most frequent soft tissue sarcoma subtypes and is characterized by a consistent deregulation of the PI3K/mTOR pathway. Cancer stem cells (CSCs) have been poorly studied in soft tissue sarcomas. In this study, we aimed to evaluate the association between...

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Detalles Bibliográficos
Autores principales: Fourneaux, Benjamin, Bourdon, Aurélien, Dadone, Bérengère, Lucchesi, Carlo, Daigle, Scott R., Richard, Elodie, Laroche-Clary, Audrey, Le Loarer, François, Italiano, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347793/
https://www.ncbi.nlm.nih.gov/pubmed/30683135
http://dx.doi.org/10.1186/s13045-018-0694-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347793/
https://www.ncbi.nlm.nih.gov/pubmed/30683135
http://dx.doi.org/10.1186/s13045-018-0694-1

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