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Identifying and targeting cancer stem cells in leiomyosarcoma: prognostic impact and role to overcome secondary resistance to PI3K/mTOR inhibition

BACKGROUND: Leiomyosarcoma (LMS) is one of the most frequent soft tissue sarcoma subtypes and is characterized by a consistent deregulation of the PI3K/mTOR pathway. Cancer stem cells (CSCs) have been poorly studied in soft tissue sarcomas. In this study, we aimed to evaluate the association between...

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Detalles Bibliográficos
Autores principales:	Fourneaux, Benjamin, Bourdon, Aurélien, Dadone, Bérengère, Lucchesi, Carlo, Daigle, Scott R., Richard, Elodie, Laroche-Clary, Audrey, Le Loarer, François, Italiano, Antoine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347793/ https://www.ncbi.nlm.nih.gov/pubmed/30683135 http://dx.doi.org/10.1186/s13045-018-0694-1

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