The use of one-stage meta-analytic method based on individual participant data for binary adverse events under the rule of three: a simulation study

OBJECTIVE: In evidence synthesis practice, dealing with binary rare adverse events (AEs) is a challenging problem. The pooled estimates for rare AEs through traditional inverse variance (IV), Mantel-Haenszel (MH), and Yusuf-Peto (Peto) methods are suboptimal, as the biases tend to be large. We propo...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Liang-Liang, Ju, Ke, Cai, Rui-Lie, Xu, Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2019
Materias:
Clinical Trials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347966/
https://www.ncbi.nlm.nih.gov/pubmed/30697486
http://dx.doi.org/10.7717/peerj.6295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347966/
https://www.ncbi.nlm.nih.gov/pubmed/30697486
http://dx.doi.org/10.7717/peerj.6295

Ejemplares similares