Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are associated with loss of nuclear TDP-43. Here we identify that TDP-43 regulates expression of the neuronal growth-associated factor stathmin-2. Lowered TDP-43 levels, which reduce its binding to sites within the first intron of...

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Detalles Bibliográficos
Autores principales: Melamed, Ze’ev, Lopez-Erauskin, Jone, Baughn, Michael W., Zhang, Ouyang, Drenner, Kevin, Sun, Ying, Freyermuth, Fernande, McMahon, Moira A., Beccari, Melinda S, Artates, Jon, Ohkubo, Takuya, Rodriguez, Maria, Lin, Nianwei, Wu, Dongmei, Bennett, C. Frank, Rigo, Frank, Da Cruz, Sandrine, Ravits, John, Lagier-Tourenne, Clotilde, Cleveland, Don W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348009/
https://www.ncbi.nlm.nih.gov/pubmed/30643298
http://dx.doi.org/10.1038/s41593-018-0293-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348009/
https://www.ncbi.nlm.nih.gov/pubmed/30643298
http://dx.doi.org/10.1038/s41593-018-0293-z

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