Non-enzymatic cleavage of Hsp90 by oxidative stress leads to actin aggregate formation: A novel gain-of-function mechanism

Aging is accompanied by the accumulation of oxidized proteins. To remove them, cells employ the proteasomal and autophagy-lysosomal systems; however, if the clearance rate is inferior to its formation, protein aggregates form as a hallmark of proteostasis loss. In cells, during stress conditions, ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Castro, José Pedro, Fernando, Raquel, Reeg, Sandra, Meinl, Walter, Almeida, Henrique, Grune, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348241/
https://www.ncbi.nlm.nih.gov/pubmed/30660959
http://dx.doi.org/10.1016/j.redox.2019.101108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348241/
https://www.ncbi.nlm.nih.gov/pubmed/30660959
http://dx.doi.org/10.1016/j.redox.2019.101108

Ejemplares similares