Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14-O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives

[Image: see text] Herein, the synthesis and pharmacological characterization of an extended library of differently substituted N-methyl-14-O-methylmorphinans with natural and unnatural amino acids and three dipeptides at position 6 that emerged as potent μ/δ opioid receptor (MOR/DOR) agonists with p...

Descripción completa

Detalles Bibliográficos
Autores principales: Spetea, Mariana, Rief, Silvia B., Haddou, Tanila Ben, Fink, Monika, Kristeva, Elka, Mittendorfer, Harald, Haas, Stefanie, Hummer, Nora, Follia, Valeria, Guerrieri, Elena, Asim, Muhammad Faheem, Sturm, Sonja, Schmidhammer, Helmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348443/
https://www.ncbi.nlm.nih.gov/pubmed/30571123
http://dx.doi.org/10.1021/acs.jmedchem.8b01327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348443/
https://www.ncbi.nlm.nih.gov/pubmed/30571123
http://dx.doi.org/10.1021/acs.jmedchem.8b01327

Ejemplares similares