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Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14-O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives

[Image: see text] Herein, the synthesis and pharmacological characterization of an extended library of differently substituted N-methyl-14-O-methylmorphinans with natural and unnatural amino acids and three dipeptides at position 6 that emerged as potent μ/δ opioid receptor (MOR/DOR) agonists with p...

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Detalles Bibliográficos
Autores principales:	Spetea, Mariana, Rief, Silvia B., Haddou, Tanila Ben, Fink, Monika, Kristeva, Elka, Mittendorfer, Harald, Haas, Stefanie, Hummer, Nora, Follia, Valeria, Guerrieri, Elena, Asim, Muhammad Faheem, Sturm, Sonja, Schmidhammer, Helmut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348443/ https://www.ncbi.nlm.nih.gov/pubmed/30571123 http://dx.doi.org/10.1021/acs.jmedchem.8b01327

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