Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis

Cells evolved robust homeostatic mechanisms to protect against oxidation or alkylation by electrophilic species. Glutathione (GSH) is the most abundant intracellular thiol, protects cellular components from oxidation and is maintained in a reduced state by glutathione reductase (GR). Nitro oleic aci...

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Detalles Bibliográficos
Autores principales: Jobbagy, Soma, Vitturi, Dario A., Salvatore, Sonia R., Turell, Lucía, Pires, Maria F., Kansanen, Emilia, Batthyany, Carlos, Lancaster, Jack R., Freeman, Bruce A., Schopfer, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348771/
https://www.ncbi.nlm.nih.gov/pubmed/30654300
http://dx.doi.org/10.1016/j.redox.2018.11.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348771/
https://www.ncbi.nlm.nih.gov/pubmed/30654300
http://dx.doi.org/10.1016/j.redox.2018.11.008

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