An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema

Hereditary angioedema (HAE) is a genetic disorder mostly caused by mutations in the C1 esterase inhibitor gene (C1INH) that results in poor control of contact pathway activation and excess bradykinin generation. Bradykinin increases vascular permeability and is ultimately responsible for the episode...

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Detalles Bibliográficos
Autores principales: Liu, Jingxuan, Qin, June, Borodovsky, Anna, Racie, Timothy, Castoreno, Adam, Schlegel, Mark, Maier, Martin A., Zimmerman, Tracy, Fitzgerald, Kevin, Butler, James, Akinc, Akin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348991/
https://www.ncbi.nlm.nih.gov/pubmed/30463937
http://dx.doi.org/10.1261/rna.068916.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348991/
https://www.ncbi.nlm.nih.gov/pubmed/30463937
http://dx.doi.org/10.1261/rna.068916.118

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