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An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema
Hereditary angioedema (HAE) is a genetic disorder mostly caused by mutations in the C1 esterase inhibitor gene (C1INH) that results in poor control of contact pathway activation and excess bradykinin generation. Bradykinin increases vascular permeability and is ultimately responsible for the episode...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348991/ https://www.ncbi.nlm.nih.gov/pubmed/30463937 http://dx.doi.org/10.1261/rna.068916.118 |