Surface Binding Energy Landscapes Affect Phosphodiesterase Isoform-Specific Inhibitor Selectivity

As human phosphodiesterase (PDE) proteins are attractive drug targets, a large number of selective PDE inhibitors have been developed. However, since the catalytic sites of PDE isoforms are conserved in sequence and structure, it remains unclear how these inhibitors discriminate PDE isoforms in a se...

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Detalles Bibliográficos
Autores principales: Liu, Qing, Herrmann, Andreas, Huang, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349013/
https://www.ncbi.nlm.nih.gov/pubmed/30719238
http://dx.doi.org/10.1016/j.csbj.2018.11.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349013/
https://www.ncbi.nlm.nih.gov/pubmed/30719238
http://dx.doi.org/10.1016/j.csbj.2018.11.009

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