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The inverted ketene synthon: a double umpolung approach to enantioselective β(2,3)-amino amide synthesis
A stereocontrolled synthesis of β(2,3)-amino amides is reported. Innovation is encapsulated by the first use of nitroalkenes to achieve double umpolung in enantioselective β-amino amide synthesis. Step economy is also fulfilled by the use of Umpolung Amide Synthesis (UmAS) in the second step, delive...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349014/ https://www.ncbi.nlm.nih.gov/pubmed/30774911 http://dx.doi.org/10.1039/c8sc04330b |