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Aminothiazoles inhibit osteoclastogenesis and PGE (2) production in LPS‐stimulated co‐cultures of periodontal ligament and RAW 264.7 cells, and RANKL‐mediated osteoclastogenesis and bone resorption in PBMCs
Inflammatory mediator prostaglandin E(2) (PGE (2)) contributes to bone resorption in several inflammatory conditions including periodontitis. The terminal enzyme, microsomal prostaglandin E synthase‐1 (mPGES‐1) regulating PGE (2) synthesis is a promising therapeutic target to reduce inflammatory bon...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349150/ https://www.ncbi.nlm.nih.gov/pubmed/30506812 http://dx.doi.org/10.1111/jcmm.14015 |