Aminothiazoles inhibit osteoclastogenesis and PGE (2) production in LPS‐stimulated co‐cultures of periodontal ligament and RAW 264.7 cells, and RANKL‐mediated osteoclastogenesis and bone resorption in PBMCs

Inflammatory mediator prostaglandin E(2) (PGE (2)) contributes to bone resorption in several inflammatory conditions including periodontitis. The terminal enzyme, microsomal prostaglandin E synthase‐1 (mPGES‐1) regulating PGE (2) synthesis is a promising therapeutic target to reduce inflammatory bon...

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Detalles Bibliográficos
Autores principales: Kats, Anna, Gerasimcik, Natalija, Näreoja, Tuomas, Nederberg, Jonas, Grenlöv, Simon, Lagnöhed, Ekaterina, Desai, Suchita, Andersson, Göran, Yucel‐Lindberg, Tülay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349150/
https://www.ncbi.nlm.nih.gov/pubmed/30506812
http://dx.doi.org/10.1111/jcmm.14015

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