Chalcone flavokawain A attenuates TGF‐β1‐induced fibrotic pathology via inhibition of ROS/Smad3 signaling pathways and induction of Nrf2/ARE‐mediated antioxidant genes in vascular smooth muscle cells

TGF‐β1 plays a crucial role in the pathogenesis of vascular fibrotic diseases. Chalcones are reportedly cancer chemo‐preventive food components that are rich in fruits and vegetables. In this study, flavokawain A (FKA, 2‐30 μM), a naturally occurring chalcone in kava extracts, was evaluated for its...

Descripción completa

Detalles Bibliográficos
Autores principales: Hseu, You‐Cheng, Yang, Ting‐Yu, Li, Mei‐Ling, Rajendran, Peramaiyan, Mathew, Dony Chacko, Tsai, Chia‐Hsuan, Lin, Ruei‐Wan, Lee, Chuan‐Chen, Yang, Hsin‐Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349172/
https://www.ncbi.nlm.nih.gov/pubmed/30549180
http://dx.doi.org/10.1111/jcmm.13973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349172/
https://www.ncbi.nlm.nih.gov/pubmed/30549180
http://dx.doi.org/10.1111/jcmm.13973

Ejemplares similares