Cargando…

Chalcone flavokawain A attenuates TGF‐β1‐induced fibrotic pathology via inhibition of ROS/Smad3 signaling pathways and induction of Nrf2/ARE‐mediated antioxidant genes in vascular smooth muscle cells

TGF‐β1 plays a crucial role in the pathogenesis of vascular fibrotic diseases. Chalcones are reportedly cancer chemo‐preventive food components that are rich in fruits and vegetables. In this study, flavokawain A (FKA, 2‐30 μM), a naturally occurring chalcone in kava extracts, was evaluated for its...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hseu, You‐Cheng, Yang, Ting‐Yu, Li, Mei‐Ling, Rajendran, Peramaiyan, Mathew, Dony Chacko, Tsai, Chia‐Hsuan, Lin, Ruei‐Wan, Lee, Chuan‐Chen, Yang, Hsin‐Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349172/ https://www.ncbi.nlm.nih.gov/pubmed/30549180 http://dx.doi.org/10.1111/jcmm.13973

Ejemplares similares

The In Vitro and In Vivo Anticancer Properties of Chalcone Flavokawain B through Induction of ROS-Mediated Apoptotic and Autophagic Cell Death in Human Melanoma Cells
por: Hseu, You-Cheng, et al.
Publicado: (2020)

Suppression of LPS-Induced Inflammation by Chalcone Flavokawain A through Activation of Nrf2/ARE-Mediated Antioxidant Genes and Inhibition of ROS/NFκB Signaling Pathways in Primary Splenocytes
por: Yang, Hsin-Ling, et al.
Publicado: (2020)

The flavokawains: uprising medicinal chalcones
por: Abu, Nadiah, et al.
Publicado: (2013)

Correction: Hseu, Y.-C., et al. The In Vitro and In Vivo Anticancer Properties of Chalcone Flavokawain B through Induction of ROS-Mediated Apoptotic and Autophagic Cell Death in Human Melanoma Cells. Cancers 2020, 12, 2936
por: Hseu, You-Cheng, et al.
Publicado: (2021)

Flavokawain B and Doxorubicin Work Synergistically to Impede the Propagation of Gastric Cancer Cells via ROS-Mediated Apoptosis and Autophagy Pathways
por: Hseu, You-Cheng, et al.
Publicado: (2020)

Anti-Apoptotic Effect of Flavokawain A on Ochratoxin-A-Induced Endothelial Cell Injury by Attenuation of Oxidative Stress via PI3K/AKT-Mediated Nrf2 Signaling Cascade
por: Rajendran, Peramaiyan, et al.
Publicado: (2021)

Flavokawain B Weakens Gastric Cancer Progression via the TGF-β1/SMAD4 Pathway and Attenuates M2 Macrophage Polarization
por: Zhu, Yongzhao, et al.
Publicado: (2022)

Anti-EMT properties of CoQ0 attributed to PI3K/AKT/NFKB/MMP-9 signaling pathway through ROS-mediated apoptosis
por: Yang, Hsin-Ling, et al.
Publicado: (2019)

Herbicidal Activity of Flavokawains and Related trans-Chalcones against Amaranthus tricolor L. and Echinochloa crus-galli (L.) Beauv.
por: Chotsaeng, Nawasit, et al.
Publicado: (2019)

Design, Synthesis and Docking Studies of Flavokawain B Type Chalcones and Their Cytotoxic Effects on MCF-7 and MDA-MB-231 Cell Lines
por: Abu Bakar, Addila, et al.
Publicado: (2018)

Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis
por: Ji, Tao, et al.
Publicado: (2013)

Dietary feeding of flavokawain A, a Kava chalcone, exhibits a satisfactory safety profile and its association with enhancement of phase II enzymes in mice
por: Li, Xuesen, et al.
Publicado: (2014)

Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin
por: Jandial, Danielle D., et al.
Publicado: (2017)

Anti-fibrotic Effects of Synthetic Oligodeoxynucleotide for TGF-β1 and Smad in an Animal Model of Liver Cirrhosis
por: Kim, Jung-Yeon, et al.
Publicado: (2017)

Design and Synthesis of Matrine Derivatives as Novel Anti-Pulmonary Fibrotic Agents via Repression of the TGFβ/Smad Pathway
por: Li, Lingyu, et al.
Publicado: (2019)

Flavokawain A is a natural inhibitor of PRMT5 in bladder cancer
por: Liu, Shuangjie, et al.
Publicado: (2022)

Flavokawain A Reduces Tumor-Initiating Properties and Stemness of Prostate Cancer
por: Song, Liankun, et al.
Publicado: (2022)

Flavokawain A alleviates the progression of mouse osteoarthritis: An in vitro and in vivo study
por: Jing, Shaoze, et al.
Publicado: (2022)

All-Trans Retinoic Acid Attenuates Fibrotic Processes by Downregulating TGF-β1/Smad3 in Early Diabetic Nephropathy
por: Sierra-Mondragon, Edith, et al.
Publicado: (2019)

Amniotic fluid-derived exosomes attenuated fibrotic changes in POI rats through modulation of the TGF-β/Smads signaling pathway
por: Nazdikbin Yamchi, Nahideh, et al.
Publicado: (2023)

Ruscogenin Protects Against Deoxynivalenol-Induced Hepatic Injury by Inhibiting Oxidative Stress, Inflammation, and Apoptosis Through the Nrf2 Signaling Pathway: An In vitro Study
por: Elsawy, Hany, et al.
Publicado: (2022)

Mangiferin Inhibits Apoptosis in Doxorubicin-Induced Vascular Endothelial Cells via the Nrf2 Signaling Pathway
por: Ismail, Mohammad Bani, et al.
Publicado: (2021)

Oxoglaucine Suppresses Hepatic Fibrosis by Inhibiting TGFβ-Induced Smad2 Phosphorylation and ROS Generation
por: Azamov, Bakhovuddin, et al.
Publicado: (2023)

Essential Role of TGF-β/Smad Pathway on Statin Dependent Vascular Smooth Muscle Cell Regulation
por: Rodríguez-Vita, Juan, et al.
Publicado: (2008)

Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol
por: Zhu, Yichen, et al.
Publicado: (2017)

C3a Receptor Antagonist Ameliorates Inflammatory and Fibrotic Signals in Type 2 Diabetic Nephropathy by Suppressing the Activation of TGF-β/smad3 and IKBα Pathway
por: Li, Ling, et al.
Publicado: (2014)

Kirenol Inhibits B[a]P-Induced Oxidative Stress and Apoptosis in Endothelial Cells via Modulation of the Nrf2 Signaling Pathway
por: Rajendran, Peramaiyan, et al.
Publicado: (2021)

The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones
por: de Freitas Silva, Matheus, et al.
Publicado: (2018)

TGF‐β/Smad and JAK/STAT pathways are involved in the anti‐fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis
por: Xu, Shizan, et al.
Publicado: (2020)

Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids
por: Zhang, Jing, et al.
Publicado: (2013)

Glycoprotein M6B Interacts with TβRI to Activate TGF‐β‐Smad2/3 Signaling and Promote Smooth Muscle Cell Differentiation
por: Zhang, Xiaomeng, et al.
Publicado: (2018)

Smad4-mediated TGF-β signaling in tumorigenesis
por: Yang, Guan, et al.
Publicado: (2010)

Cardiac Protective Effect of Kirenol against Doxorubicin-Induced Cardiac Hypertrophy in H9c2 Cells through Nrf2 Signaling via PI3K/AKT Pathways
por: Alzahrani, Abdullah M., et al.
Publicado: (2021)

SUMOylation of Smad2 mediates TGF-β-regulated endothelial–mesenchymal transition
por: Su, Qi, et al.
Publicado: (2023)

PPARγ/NF‐κB and TGF‐β1/Smad pathway are involved in the anti‐fibrotic effects of levo‐tetrahydropalmatine on liver fibrosis
por: Yu, Qiang, et al.
Publicado: (2021)

A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls
por: Rapado, Ludmila N., et al.
Publicado: (2014)

Fructose Induces Pulmonary Fibrotic Phenotype Through Promoting Epithelial-Mesenchymal Transition Mediated by ROS-Activated Latent TGF-β1
por: Xu, Xiaoxiao, et al.
Publicado: (2022)

Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation
por: Wójcik-Pszczoła, Katarzyna, et al.
Publicado: (2022)

Honokiol Acts as a Potent Anti-Fibrotic Agent in the Liver through Inhibition of TGF-β1/SMAD Signaling and Autophagy in Hepatic Stellate Cells
por: Kataoka, Seita, et al.
Publicado: (2021)

Smad2 and Smad3 have differential sensitivity in relaying TGFβ signaling and inversely regulate early lineage specification
por: Liu, Ling, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_0o7os3o1ijtlme1drrvs5mt8vf