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MiR‐15a/16‐1 deficiency induces IL‐10‐producing CD19(+) TIM‐1(+) cells in tumor microenvironment

IL‐10‐producing B cells (B10) are associated with autoimmune diseases, infection and tumours. MiR‐15a/16 as a tumour‐suppressive gene is down‐regulated in several tumours, such as chronic lymphocytic leukaemia, pituitary adenomas and prostate carcinoma. Here, increased frequency of IL‐10‐producing C...

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Detalles Bibliográficos
Autores principales: Jia, Xiaoqin, Liu, Hao, Xu, Chong, Han, Sen, Shen, Yating, Miao, Xin, Hu, Xiangyu, Lin, Zhijie, Qian, Li, Wang, Zhengbing, Gong, Weijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349175/
https://www.ncbi.nlm.nih.gov/pubmed/30467955
http://dx.doi.org/10.1111/jcmm.14037