Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell

As a natural flavonol, fisetin has significant inhibitory effects on many cancers. Although fisetin can inhibit kidney cancer, its effects on kidney renal stem cells (HuRCSCs) remain unknown. Our study found that renal cancer tissues and CD44+/CD105+ HuRCSCs both show high TET1 protein expression. B...

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Detalles Bibliográficos
Autores principales: Si, Yibing, Liu, Junfeng, Shen, Hongliang, Zhang, Chen, Wu, Yuanhao, Huang, Yongyi, Gong, Zhangbin, Xue, Jun, Liu, Te
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349178/
https://www.ncbi.nlm.nih.gov/pubmed/30411496
http://dx.doi.org/10.1111/jcmm.14010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349178/
https://www.ncbi.nlm.nih.gov/pubmed/30411496
http://dx.doi.org/10.1111/jcmm.14010

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