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Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell
As a natural flavonol, fisetin has significant inhibitory effects on many cancers. Although fisetin can inhibit kidney cancer, its effects on kidney renal stem cells (HuRCSCs) remain unknown. Our study found that renal cancer tissues and CD44+/CD105+ HuRCSCs both show high TET1 protein expression. B...
Autores principales: | Si, Yibing, Liu, Junfeng, Shen, Hongliang, Zhang, Chen, Wu, Yuanhao, Huang, Yongyi, Gong, Zhangbin, Xue, Jun, Liu, Te |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349178/ https://www.ncbi.nlm.nih.gov/pubmed/30411496 http://dx.doi.org/10.1111/jcmm.14010 |
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