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A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels
Piezo1 and Piezo2 belong to a family of mechanically-activated ion channels implicated in a wide range of physiological processes. Mechanical stimulation triggers Piezo channels to open, but their characteristic fast inactivation process results in rapid closure. Several disease-causing mutations in...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349400/ https://www.ncbi.nlm.nih.gov/pubmed/30628892 http://dx.doi.org/10.7554/eLife.44003 |