Synaptotagmin oligomers are necessary and can be sufficient to form a Ca(2+)‐sensitive fusion clamp

The buttressed‐ring hypothesis, supported by recent cryo‐electron tomography analysis of docked synaptic‐like vesicles in neuroendocrine cells, postulates that prefusion SNAREpins are stabilized and organized by Synaptotagmin (Syt) ring‐like oligomers. Here, we use a reconstituted single‐vesicle fus...

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Detalles Bibliográficos
Autores principales: Ramakrishnan, Sathish, Bera, Manindra, Coleman, Jeff, Krishnakumar, Shyam S., Pincet, Frederic, Rothman, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349546/
https://www.ncbi.nlm.nih.gov/pubmed/30570144
http://dx.doi.org/10.1002/1873-3468.13317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349546/
https://www.ncbi.nlm.nih.gov/pubmed/30570144
http://dx.doi.org/10.1002/1873-3468.13317

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