PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity

Prognosis of patients with glioblastoma (GBM) remains dismal despite maximal surgical resection followed by aggressive chemo-radiation therapy. Almost every GBM, regardless of genotype, relapses as aggressive recurrent disease. Sensitization of GBM cells to chemo-radiation is expected to extend surv...

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Detalles Bibliográficos
Autores principales: Gupta, Shiv K., Smith, Emily J., Mladek, Ann C., Tian, Shulan, Decker, Paul A., Kizilbash, Sani H., Kitange, Gaspar J., Sarkaria, Jann N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349736/
https://www.ncbi.nlm.nih.gov/pubmed/30723695
http://dx.doi.org/10.3389/fonc.2018.00670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349736/
https://www.ncbi.nlm.nih.gov/pubmed/30723695
http://dx.doi.org/10.3389/fonc.2018.00670

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