A Guide to PIN1 Function and Mutations Across Cancers

PIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis–trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability. PIN1 is overexpressed in human cancers, suggesting it promotes tumor...

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Autores principales: El Boustani, Maguie, De Stefano, Lucia, Caligiuri, Isabella, Mouawad, Nayla, Granchi, Carlotta, Canzonieri, Vincenzo, Tuccinardi, Tiziano, Giordano, Antonio, Rizzolio, Flavio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349750/
https://www.ncbi.nlm.nih.gov/pubmed/30723410
http://dx.doi.org/10.3389/fphar.2018.01477
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author El Boustani, Maguie
De Stefano, Lucia
Caligiuri, Isabella
Mouawad, Nayla
Granchi, Carlotta
Canzonieri, Vincenzo
Tuccinardi, Tiziano
Giordano, Antonio
Rizzolio, Flavio
author_facet El Boustani, Maguie
De Stefano, Lucia
Caligiuri, Isabella
Mouawad, Nayla
Granchi, Carlotta
Canzonieri, Vincenzo
Tuccinardi, Tiziano
Giordano, Antonio
Rizzolio, Flavio
author_sort El Boustani, Maguie
collection PubMed
description PIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis–trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability. PIN1 is overexpressed in human cancers, suggesting it promotes tumorigenesis, but depending on the cellular context, it also acts as a tumor suppressor. Here, we review the role of PIN1 in cancer and the regulation of PIN1 expression, and catalog the single nucleotide polymorphisms, and mutations in PIN1 gene associated with cancer. In addition, we provide a 3D model of the protein to localize the mutated residues.
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spelling pubmed-63497502019-02-05 A Guide to PIN1 Function and Mutations Across Cancers El Boustani, Maguie De Stefano, Lucia Caligiuri, Isabella Mouawad, Nayla Granchi, Carlotta Canzonieri, Vincenzo Tuccinardi, Tiziano Giordano, Antonio Rizzolio, Flavio Front Pharmacol Pharmacology PIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis–trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability. PIN1 is overexpressed in human cancers, suggesting it promotes tumorigenesis, but depending on the cellular context, it also acts as a tumor suppressor. Here, we review the role of PIN1 in cancer and the regulation of PIN1 expression, and catalog the single nucleotide polymorphisms, and mutations in PIN1 gene associated with cancer. In addition, we provide a 3D model of the protein to localize the mutated residues. Frontiers Media S.A. 2019-01-22 /pmc/articles/PMC6349750/ /pubmed/30723410 http://dx.doi.org/10.3389/fphar.2018.01477 Text en Copyright © 2019 El Boustani, De Stefano, Caligiuri, Mouawad, Granchi, Canzonieri, Tuccinardi, Giordano and Rizzolio. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
El Boustani, Maguie
De Stefano, Lucia
Caligiuri, Isabella
Mouawad, Nayla
Granchi, Carlotta
Canzonieri, Vincenzo
Tuccinardi, Tiziano
Giordano, Antonio
Rizzolio, Flavio
A Guide to PIN1 Function and Mutations Across Cancers
title A Guide to PIN1 Function and Mutations Across Cancers
title_full A Guide to PIN1 Function and Mutations Across Cancers
title_fullStr A Guide to PIN1 Function and Mutations Across Cancers
title_full_unstemmed A Guide to PIN1 Function and Mutations Across Cancers
title_short A Guide to PIN1 Function and Mutations Across Cancers
title_sort guide to pin1 function and mutations across cancers
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349750/
https://www.ncbi.nlm.nih.gov/pubmed/30723410
http://dx.doi.org/10.3389/fphar.2018.01477
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