Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis

The origin and physiological significance of lipid droplets (LDs) in the nucleus is not clear. Here we show that nuclear LDs in hepatocytes are derived from apolipoprotein B (ApoB)-free lumenal LDs, a precursor to very low-density lipoproprotein (VLDL) generated in the ER lumen by microsomal triglyc...

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Detalles Bibliográficos
Autores principales: Sołtysik, Kamil, Ohsaki, Yuki, Tatematsu, Tsuyako, Cheng, Jinglei, Fujimoto, Toyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349838/
https://www.ncbi.nlm.nih.gov/pubmed/30692541
http://dx.doi.org/10.1038/s41467-019-08411-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349838/
https://www.ncbi.nlm.nih.gov/pubmed/30692541
http://dx.doi.org/10.1038/s41467-019-08411-x

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