Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures

Reactive oxygen species (ROS) function as second messengers in signal transduction, but high ROS levels can also cause cell death. MTH1 dephosphorylates oxidized nucleotides, thereby preventing their incorporation into DNA and protecting tumour cells from oxidative DNA damage. Inhibitors of MTH1 (TH...

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Detalles Bibliográficos
Autores principales: van der Waals, Lizet M., Laoukili, Jamila, Jongen, Jennifer M. J., Raats, Danielle A., Borel Rinkes, Inne H. M., Kranenburg, Onno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349914/
https://www.ncbi.nlm.nih.gov/pubmed/30692572
http://dx.doi.org/10.1038/s41598-018-37316-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349914/
https://www.ncbi.nlm.nih.gov/pubmed/30692572
http://dx.doi.org/10.1038/s41598-018-37316-w

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