ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells

Anti-silencing function 1a (ASF1a) is a histone H3–H4 chaperone isoform involved in chromatin assembling and transcription regulation. Recently, ASF1a has been shown to be up-regulated in certain human malignancies and required for the expression of telomerase reverse transcriptase (TERT), a factor...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Yujiao, Li, Xidan, Yu, Jingya, Björkholm, Magnus, Xu, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349940/
https://www.ncbi.nlm.nih.gov/pubmed/30692519
http://dx.doi.org/10.1038/s41419-019-1357-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349940/
https://www.ncbi.nlm.nih.gov/pubmed/30692519
http://dx.doi.org/10.1038/s41419-019-1357-z

Ejemplares similares