Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity

We report the evaluation of 265 compounds from a PDE-focused library for their antischistosomal activity, assessed in vitro using Schistosoma mansoni. Of the tested compounds, 171 (64%) displayed selective in vitro activity, with 16 causing worm hypermotility/spastic contractions and 41 inducing var...

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Detalles Bibliográficos
Autores principales: Botros, Sanaa S., William, Samia, Sabra, Abdel-Nasser A., El-Lakkany, Naglaa M., Seif el-Din, Sayed H., García-Rubia, Alfonso, Sebastián-Pérez, Victor, Blaazer, Antoni R., de Heuvel, Erik, Sijm, Maarten, Zheng, Yang, Salado, Irene G., Munday, Jane C., Maes, Louis, de Esch, Iwan J.P., Sterk, Geert J., Augustyns, Koen, Leurs, Rob, Gil, Carmen, De Koning, Harry P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350229/
https://www.ncbi.nlm.nih.gov/pubmed/30669086
http://dx.doi.org/10.1016/j.ijpddr.2019.01.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350229/
https://www.ncbi.nlm.nih.gov/pubmed/30669086
http://dx.doi.org/10.1016/j.ijpddr.2019.01.001

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