Nucleotide Modification Alters MicroRNA-Dependent Silencing of MicroRNA Switches

mRNA therapeutics hold great promise for the treatment of human diseases. While incorporating naturally occurring modified nucleotides during synthesis has greatly increased their potency and safety, challenges in selective expression have hindered clinical applications. MicroRNA (miRNA)-regulated i...

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Detalles Bibliográficos
Autores principales: Lockhart, John, Canfield, John, Mong, Ezinne Francess, VanWye, Jeffrey, Totary-Jain, Hana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350232/
https://www.ncbi.nlm.nih.gov/pubmed/30665183
http://dx.doi.org/10.1016/j.omtn.2018.12.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350232/
https://www.ncbi.nlm.nih.gov/pubmed/30665183
http://dx.doi.org/10.1016/j.omtn.2018.12.007

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