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Nucleotide Modification Alters MicroRNA-Dependent Silencing of MicroRNA Switches
mRNA therapeutics hold great promise for the treatment of human diseases. While incorporating naturally occurring modified nucleotides during synthesis has greatly increased their potency and safety, challenges in selective expression have hindered clinical applications. MicroRNA (miRNA)-regulated i...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350232/ https://www.ncbi.nlm.nih.gov/pubmed/30665183 http://dx.doi.org/10.1016/j.omtn.2018.12.007 |