Re-formulating Gehan’s design as a flexible two-stage single-arm trial

BACKGROUND: Gehan’s two-stage design was historically the design of choice for phase II oncology trials. One of the reasons it is less frequently used today is that it does not allow for a formal test of treatment efficacy, and therefore does not control conventional type-I and type-II error-rates....

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Detalles Bibliográficos
Autores principales: Grayling, Michael J., Mander, Adrian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350340/
https://www.ncbi.nlm.nih.gov/pubmed/30691398
http://dx.doi.org/10.1186/s12874-019-0659-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350340/
https://www.ncbi.nlm.nih.gov/pubmed/30691398
http://dx.doi.org/10.1186/s12874-019-0659-2

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