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Re-formulating Gehan’s design as a flexible two-stage single-arm trial
BACKGROUND: Gehan’s two-stage design was historically the design of choice for phase II oncology trials. One of the reasons it is less frequently used today is that it does not allow for a formal test of treatment efficacy, and therefore does not control conventional type-I and type-II error-rates....
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350340/ https://www.ncbi.nlm.nih.gov/pubmed/30691398 http://dx.doi.org/10.1186/s12874-019-0659-2 |