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Development of a peptide-based fluorescent probe for biological heme monitoring

Heme plays a vital role in cell biology and dysregulation of heme levels is implicated in a wide range of diseases. However, monitoring heme levels in biological systems is currently not straightforward. A short synthetic peptide probe containing 7-azatryptophan is shown to bind hemin in vitro with...

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Detalles Bibliográficos
Autores principales: Newton, Laura D., Pascu, Sofia I., Tyrrell, Rex M., Eggleston, Ian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350759/
https://www.ncbi.nlm.nih.gov/pubmed/30574967
http://dx.doi.org/10.1039/c8ob02290a