Unique and overlapping GLI1 and GLI2 transcriptional targets in neoplastic chondrocytes

Excessive Hedgehog (Hh) signaling in chondrocytes is sufficient to cause formation of enchondroma-like lesions which can progress to chondrosarcoma. To elucidate potential underlying mechanisms, we identified GLI1 and GLI2 target genes in human chondrosarcoma. Using chromatin immunoprecipitation (Ch...

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Detalles Bibliográficos
Autores principales: Ali, Shabana Amanda, Niu, Ben, Cheah, Kathryn S. E., Alman, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350985/
https://www.ncbi.nlm.nih.gov/pubmed/30695055
http://dx.doi.org/10.1371/journal.pone.0211333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350985/
https://www.ncbi.nlm.nih.gov/pubmed/30695055
http://dx.doi.org/10.1371/journal.pone.0211333

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