CD4 occupancy triggers sequential pre-fusion conformational states of the HIV-1 envelope trimer with relevance for broadly neutralizing antibody activity

During the entry process, the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer undergoes a sequence of conformational changes triggered by both CD4 and coreceptor engagement. Resolving the conformation of these transient entry intermediates has proven challenging. Here,...

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Detalles Bibliográficos
Autores principales: Ivan, Branislav, Sun, Zhaozhi, Subbaraman, Harini, Friedrich, Nikolas, Trkola, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351000/
https://www.ncbi.nlm.nih.gov/pubmed/30650070
http://dx.doi.org/10.1371/journal.pbio.3000114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351000/
https://www.ncbi.nlm.nih.gov/pubmed/30650070
http://dx.doi.org/10.1371/journal.pbio.3000114

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