Cargando…

CD4 occupancy triggers sequential pre-fusion conformational states of the HIV-1 envelope trimer with relevance for broadly neutralizing antibody activity

During the entry process, the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer undergoes a sequence of conformational changes triggered by both CD4 and coreceptor engagement. Resolving the conformation of these transient entry intermediates has proven challenging. Here,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ivan, Branislav, Sun, Zhaozhi, Subbaraman, Harini, Friedrich, Nikolas, Trkola, Alexandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351000/ https://www.ncbi.nlm.nih.gov/pubmed/30650070 http://dx.doi.org/10.1371/journal.pbio.3000114

Ejemplares similares

Broadly neutralizing antibodies: What is needed to move from a rare event in HIV-1 infection to vaccine efficacy?
por: Subbaraman, Harini, et al.
Publicado: (2018)

Assessing immunogenicity barriers of the HIV-1 envelope trimer
por: Maliqi, Liridona, et al.
Publicado: (2023)

Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization
por: Friedrich, Nikolas, et al.
Publicado: (2021)

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability
por: Dubrovskaya, Viktoriya, et al.
Publicado: (2019)

Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers
por: Koch, Kathrin, et al.
Publicado: (2017)

Multiple conformations of trimeric spikes visualized on a non-enveloped virus
por: Zhang, Yinong, et al.
Publicado: (2022)

Different Infectivity of HIV-1 Strains Is Linked to Number of Envelope Trimers Required for Entry
por: Brandenberg, Oliver F., et al.
Publicado: (2015)

Stabilizing HIV-1 envelope glycoprotein trimers to induce neutralizing antibodies
por: Torrents de la Peña, Alba, et al.
Publicado: (2018)

Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity
por: Prigent, Julie, et al.
Publicado: (2018)

Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization
por: Glögl, Matthias, et al.
Publicado: (2023)

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo
por: Medina-Ramírez, Max, et al.
Publicado: (2017)

Quaternary Interaction of the HIV-1 Envelope Trimer with CD4 and Neutralizing Antibodies
por: Liu, Qingbo, et al.
Publicado: (2021)

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies
por: LaBranche, Celia C., et al.
Publicado: (2019)

Stabilization of the V2 loop improves the presentation of V2 loop–associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers
por: de Taeye, Steven W., et al.
Publicado: (2019)

A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure
por: Lee, Jeong Hyun, et al.
Publicado: (2017)

Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies
por: Ratnapriya, Sneha, et al.
Publicado: (2023)

Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage
por: Reh, Lucia, et al.
Publicado: (2018)

Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies
por: LaBranche, Celia C., et al.
Publicado: (2019)

Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers
por: Schorcht, Anna, et al.
Publicado: (2020)

Interaction of the gp120 V1V2 loop with a neighboring gp120 unit shields the HIV envelope trimer against cross-neutralizing antibodies
por: Rusert, Peter, et al.
Publicado: (2011)

Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike
por: Derking, Ronald, et al.
Publicado: (2021)

The Glycan Hole Area of HIV-1 Envelope Trimers Contributes Prominently to the Induction of Autologous Neutralization
por: Schorcht, Anna, et al.
Publicado: (2022)

Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation
por: Guzzo, Christina, et al.
Publicado: (2018)

Asymmetric conformations of cleaved HIV-1 envelope glycoprotein trimers in styrene-maleic acid lipid nanoparticles
por: Wang, Kunyu, et al.
Publicado: (2023)

HIV-1 envelope trimer elicits higher neutralizing antibody responses than monomeric gp120
por: Kovacs, JM, et al.
Publicado: (2012)

High thermostability improves neutralizing antibody responses induced by native-like HIV-1 envelope trimers
por: del Moral-Sánchez, Iván, et al.
Publicado: (2022)

Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles
por: Kumar, Sonu, et al.
Publicado: (2021)

Random sequential adsorption of trimers and hexamers
por: Cieśla, Michał, et al.
Publicado: (2013)

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope
por: Schoofs, Till, et al.
Publicado: (2019)

Strategies for induction of HIV‐1 envelope‐reactive broadly neutralizing antibodies
por: Williams, Wilton B., et al.
Publicado: (2021)

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques
por: Klasse, P. J., et al.
Publicado: (2018)

Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer
por: Xu, Ziyang, et al.
Publicado: (2022)

A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding
por: Wang, Yingdan, et al.
Publicado: (2022)

Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations
por: Williams, Wilton B., et al.
Publicado: (2017)

Improving the immunogenicity of HIV-1 envelope trimer vaccines
por: Sanders, Rogier W
Publicado: (2011)

Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens
por: Sattentau, Quentin J.
Publicado: (2013)

Immunization of Rabbits with Highly Purified, Soluble, Trimeric Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Induces a Vigorous B Cell Response and Broadly Cross-Reactive Neutralization
por: Quinnan, Gerald V., et al.
Publicado: (2014)

Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations
por: Duenas-Decamp, Maria, et al.
Publicado: (2016)

Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics
por: Torrents de la Peña, Alba, et al.
Publicado: (2019)

Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C
por: Klasse, P. J., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_cuhc7j7732iba5u14eufr80tuj