The Preferable Binding Pose of Canonical Butyrylcholinesterase Substrates Is Unproductive for Echothiophate

In this paper, we, for the first time, describe the interaction between the butyrylcholinesterase enzyme and echothiophate, a popular model compound and an analogue of the chemical warfare agents VX and VR, at the atomistic level. Competition between the two echothiophate conformations in the active...

Descripción completa

Detalles Bibliográficos
Autores principales: Zlobin, A. S., Zalevsky, A. O., Mokrushina, Yu. A., Kartseva, O. V., Golovin, A. V., Smirnov, I. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351040/
https://www.ncbi.nlm.nih.gov/pubmed/30713771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351040/
https://www.ncbi.nlm.nih.gov/pubmed/30713771

Ejemplares similares