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Lineage tracing of Notch1-expressing cells in intestinal tumours reveals a distinct population of cancer stem cells
Colon tumours are hierarchically organized and contain multipotent self-renewing cells, called Cancer Stem Cells (CSCs). We have previously shown that the Notch1 receptor is expressed in Intestinal Stem Cells (ISCs); given the critical role played by Notch signalling in promoting intestinal tumourig...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351556/ https://www.ncbi.nlm.nih.gov/pubmed/30696875 http://dx.doi.org/10.1038/s41598-018-37301-3 |