Activated MEK/ERK Pathway Drives Widespread and Coordinated Overexpression of UHRF1 and DNMT1 in Cancer cells

The UHRF1-DNMT1 axis plays a key role in DNA maintenance methylation in mammals. Accumulative studies demonstrate that UHRF1 is broadly overexpressed in cancers, which contributes to cancer cell proliferation and tumorigenesis. Interestingly, a proteasome-dependent downregulation of UHRF1 has been o...

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Detalles Bibliográficos
Autores principales: Li, Jialun, Wang, Ruiping, Hu, Xueli, Gao, Yingying, Wang, Zhen, Li, Jiwen, Wong, Jiemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351616/
https://www.ncbi.nlm.nih.gov/pubmed/30696879
http://dx.doi.org/10.1038/s41598-018-37258-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351616/
https://www.ncbi.nlm.nih.gov/pubmed/30696879
http://dx.doi.org/10.1038/s41598-018-37258-3

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