Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary function in developing zebrafish

Patients with an inherited inability to synthesize sufficient amounts of cholesterol develop congenital malformations of the skull, toes, kidney and heart. As development of these structures depends on functional cilia we investigated whether cholesterol regulates ciliogenesis through inhibition of...

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Detalles Bibliográficos
Autores principales: Maerz, Lars D., Burkhalter, Martin D., Schilpp, Carolin, Wittekindt, Oliver H., Frick, Manfred, Philipp, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351647/
https://www.ncbi.nlm.nih.gov/pubmed/30729178
http://dx.doi.org/10.1038/s42003-018-0272-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351647/
https://www.ncbi.nlm.nih.gov/pubmed/30729178
http://dx.doi.org/10.1038/s42003-018-0272-7

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