Development of an oligonucleotide microarray for simultaneous detection of two canine MDR1 genotypes and association between genotypes and chemotherapy side effects

Canine MDR1 gene mutations produce translated P-glycoprotein, an active drug efflux transporter, resulting in dysfunction or over-expression. The 4-base deletion at exon 4 of MDR1 at nucleotide position 230 (nt230[del4]) in exon 4 makes P-glycoprotein lose function, leading to drug accumulation and...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jih-Jong, Lin, Han-You, Chen, Chun-An, Lin, Chen-Si, Wang, Lih-Chiann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351760/
https://www.ncbi.nlm.nih.gov/pubmed/30481983
http://dx.doi.org/10.4142/jvs.2019.20.1.27

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351760/
https://www.ncbi.nlm.nih.gov/pubmed/30481983
http://dx.doi.org/10.4142/jvs.2019.20.1.27

Ejemplares similares