Lymph nodes as barriers to T‐cell rejuvenation in aging mice and nonhuman primates

In youth, thymic involution curtails production of new naïve T cells, placing the onus of T‐cell maintenance upon secondary lymphoid organs (SLO). This peripheral maintenance preserves the size of the T‐cell pool for much of the lifespan, but wanes in the last third of life, leading to a dearth of n...

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Detalles Bibliográficos
Autores principales: Thompson, Heather L., Smithey, Megan J., Uhrlaub, Jennifer L., Jeftić, Ilija, Jergović, Mladen, White, Sarah E., Currier, Noreen, Lang, Anna M., Okoye, Afam, Park, Byung, Picker, Louis J., Surh, Charles D., Nikolich‐Žugich, Janko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351843/
https://www.ncbi.nlm.nih.gov/pubmed/30430748
http://dx.doi.org/10.1111/acel.12865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351843/
https://www.ncbi.nlm.nih.gov/pubmed/30430748
http://dx.doi.org/10.1111/acel.12865

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