Cargando…

Amyloid β perturbs elevated heme flux induced with neuronal development

INTRODUCTION: Heme is a central molecule in mitochondrial respiration and ATP generation in neuronal cells. Thus, we assessed the importance of altered heme metabolism in Alzheimer's disease (AD) pathogenesis. METHODS: To investigate the role of altered heme metabolism in AD, we identified heme...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vidal, Chantal, Daescu, Kelly, Fitzgerald, Keely E., Starokadomska, Anna, Bezprozvanny, Ilya, Zhang, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Featured Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352316/ https://www.ncbi.nlm.nih.gov/pubmed/30723777 http://dx.doi.org/10.1016/j.trci.2018.12.003

Ejemplares similares

Essential roles of mitochondrial and heme function in lung cancer bioenergetics and tumorigenesis
por: Kalainayakan, Sarada Preeta, et al.
Publicado: (2018)

The vascular disrupting agent combretastatin A-4 phosphate causes prolonged elevation of proteins involved in heme flux and function in resistant tumor cells
por: Dey, Sanchareeka, et al.
Publicado: (2017)

In vitro degradation of β-amyloid fibrils by microbial keratinase
por: Ningthoujam, Debananda S., et al.
Publicado: (2019)

Dietary patterns and β-amyloid deposition in aging Australian women
por: Hill, Edward, et al.
Publicado: (2018)

Normal cerebrospinal fluid concentrations of PDGFRβ in patients with cerebral amyloid angiopathy and Alzheimer's disease
por: De Kort, Anna M., et al.
Publicado: (2021)

NPT088 reduces both amyloid-β and tau pathologies in transgenic mice
por: Levenson, Jonathan M., et al.
Publicado: (2016)

Heme-Thiolate Perturbation in Cystathionine β-Synthase by Mercury Compounds
por: Benchoam, Dayana, et al.
Publicado: (2021)

Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease
por: Frederiksen, Kristian S., et al.
Publicado: (2019)

Amyloid-β oligomers suppress subunit-specific glutamate receptor increase during LTP
por: Tanaka, Hiromitsu, et al.
Publicado: (2019)

Established amyloid-β pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine
por: Severino, Maurizio, et al.
Publicado: (2018)

UB-311, a novel UBITh(®) amyloid β peptide vaccine for mild Alzheimer's disease
por: Wang, Chang Yi, et al.
Publicado: (2017)

Mild behavioral impairment is associated with β‐amyloid but not tau or neurodegeneration in cognitively intact elderly individuals
por: Lussier, Firoza Z., et al.
Publicado: (2020)

First amyloid β1‐42 certified reference material for re‐calibrating commercial immunoassays
por: Boulo, Sébastien, et al.
Publicado: (2020)

A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects
por: Ghosal, Kaushik, et al.
Publicado: (2016)

Molecular crowding effects on the biochemical properties of amyloid β–heme, Aβ–Cu and Aβ–heme–Cu complexes
por: Li, Meng, et al.
Publicado: (2020)

Cerebral amyloid‐β load is associated with neurodegeneration and gliosis: Mediation by p‐tau and interactions with risk factors early in the Alzheimer's continuum
por: Salvadó, Gemma, et al.
Publicado: (2021)

Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo
por: Steele, John W, et al.
Publicado: (2009)

Prevalence of cerebral amyloid angiopathy: A systematic review and meta‐analysis
por: Jäkel, Lieke, et al.
Publicado: (2021)

Neurons from skin mimic brain holes
por: Bezprozvanny, Ilya, et al.
Publicado: (2016)

Epoxide hydrolysis as a model system for understanding flux through a branched reaction scheme
por: Janfalk Carlsson, Åsa, et al.
Publicado: (2018)

The pattern of amyloid accumulation in the brains of adults with Down syndrome
por: Annus, Tiina, et al.
Publicado: (2016)

Biomathematical screening of amyloid radiotracers with clinical usefulness index
por: Nai, Ying-Hwey, et al.
Publicado: (2017)

Characteristics of subjective cognitive decline associated with amyloid positivity
por: Janssen, Olin, et al.
Publicado: (2021)

A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study
por: Villemagne, Victor L., et al.
Publicado: (2017)

NGP 555, a γ-secretase modulator, lowers the amyloid biomarker, Aβ(42,) in cerebrospinal fluid while preventing Alzheimer's disease cognitive decline in rodents
por: Kounnas, Maria Z., et al.
Publicado: (2016)

Exact conditions for preservation of the partial indices of a perturbed triangular 2 × 2 matrix function
por: Adukov, Victor M., et al.
Publicado: (2020)

Amyloid β and free heme: bloody new insights into the pathogenesis of Alzheimer’s disease
por: Flemmig, Jörg, et al.
Publicado: (2018)

Amyloid-associated increases in longitudinal report of subjective cognitive complaints
por: Amariglio, Rebecca E., et al.
Publicado: (2018)

Is amyloid involved in acute neuroinflammation? A CSF analysis in encephalitis
por: Padovani, Alessandro, et al.
Publicado: (2022)

Brain imaging measurements of fibrillar amyloid‐β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele
por: Ghisays, Valentina, et al.
Publicado: (2020)

Deep residual inception encoder‐decoder network for amyloid PET harmonization
por: Shah, Jay, et al.
Publicado: (2022)

Patient Perspectives on Managing Type 1 Diabetes During High-Performance Exercise: What Resources Do They Want?
por: Dizon, Stephanie, et al.
Publicado: (2019)

Cytoskeleton Protein EB3 Contributes to Dendritic Spines Enlargement and Enhances Their Resilience to Toxic Effects of Beta-Amyloid
por: Pchitskaya, Ekaterina, et al.
Publicado: (2022)

Ganglion cell layer thinning in prodromal Alzheimer's disease defined by amyloid PET
por: López-de-Eguileta, Alicia, et al.
Publicado: (2019)

Quantitative amyloid PET in Alzheimer's disease: the AMYPAD prognostic and natural history study
por: Lopes Alves, Isadora, et al.
Publicado: (2020)

Commentary on “Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice”
por: Popugaeva, Elena, et al.
Publicado: (2014)

Non-neuronal and neuronal BACE1 elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain
por: Xue, Zhi-Qin, et al.
Publicado: (2015)

A Recipe for ORANGE-CAKE—This Time with Two Layers!
por: Duff, Keely
Publicado: (2022)

Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum
por: Milà‐Alomà, Marta, et al.
Publicado: (2020)

Distinct effects of beta‐amyloid and tau on cortical thickness in cognitively healthy older adults
por: Harrison, Theresa M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dvfsppbdkjjiuii96r3gl7a3at