Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal α-actinin-4 expression and stabilizing integrin-cytoskeleton linkage

BACKGROUND: Glomerulonephritis is one of the major complications and causes of death in systemic lupus erythematosus (SLE) and is characterized by glomerulosclerosis, interstitial fibrosis, and tubular atrophy, along with severe persistent proteinuria. DZ2002 is a reversible S-adenosyl-l-homocystein...

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Detalles Bibliográficos
Autores principales: He, Shijun, Liu, Xing, Lin, Zemin, Liu, Yuting, Gu, Lei, Zhou, Hu, Tang, Wei, Zuo, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352376/
https://www.ncbi.nlm.nih.gov/pubmed/30696480
http://dx.doi.org/10.1186/s13075-019-1820-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352376/
https://www.ncbi.nlm.nih.gov/pubmed/30696480
http://dx.doi.org/10.1186/s13075-019-1820-3

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